Award
National Institute on Aging 4R01AG081767-02
Frontal and Temporal Lobe Interactions in Rat Models of Normative Aging and Alzheimer's Disease
Recipient
University of Arizona, Tucson, AZ
Award Amount
$729,295.00
Ceiling
$729,295.00
Awarded
June 09, 2026
Identifier
4R01AG081767-02
Research project funded by the National Institute on Aging to study brain circuit interactions in rat models to understand cognitive aging and Alzheimer's disease, using advanced neural recording technology.
Description
This project aims to understand how brain circuit interactions critical for memory are altered in both normal aging and in neurodegenerative disease, focusing on the interactions between the hippocampus and the medial prefrontal cortex (mPFC). It uses behavioral and electrophysiological methods, including high-density Neuropixels probes, to study neural interactions in rat models of aging and Alzheimer's disease.