Award
NIH Reporter #5R01DK044319-34
Characterization of Mucosal Lymphocytes
Recipient
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Award Amount
$666,550.00
Ceiling
$666,550.00
Awarded
July 08, 2026
Identifier
5R01DK044319-34
This NIH-funded project studies the role of early-life stromal cells and microbial signals in shaping gut immune cell niches, aiming to understand mechanisms influencing susceptibility to inflammatory bowel disease and other mucosal diseases.
Description
The research investigates how early-life stromal cells and microbial signals shape immune cell niches in the gut, influencing susceptibility to inflammatory bowel disease and other mucosal diseases later in life. The study involves characterizing stromal cell populations marked by Wnt4, their molecular signals such as BMP2, and their interactions with iNKT cells during critical developmental windows.