Award
NIH Reporter #5R01HL169202-03
Molecular mechanisms of progranulin as a regulator of endothelial biology and blood pressure control
Recipient
University of South Alabama, Mobile, AL, United States
Award Amount
$463,961.00
Ceiling
$463,961.00
Awarded
June 03, 2026
Identifier
5R01HL169202-03
This NIH-funded project aims to elucidate the molecular pathways involving progranulin in endothelial cells and their impact on hypertension, with potential implications for developing novel therapeutics.
Description
Endothelial cell dysfunction initiates hypertension, with progranulin (PGRN) identified as a novel regulator. The study investigates PGRN's role in endothelial function and blood pressure regulation, including its degradation by ACE and effects on AMPK and Nox1 activity.