Award
National Heart, Lung, and Blood Institute 5R01HL141353-09
Metabolic Impact and Mechanism of Enhanced Mitochondrial Calcium Uptake in Mitochondrial Cardiomyopathies
Recipient
Utah State Higher Education System--University of Utah, Salt Lake City, UT
Award Amount
$578,928.00
Ceiling
$578,928.00
Awarded
April 09, 2026
Identifier
5R01HL141353-09
Research project funded by NHLBI to study mitochondrial calcium regulation and its impact on mitochondrial cardiomyopathies, aiming to identify new therapeutic targets.
Description
The project investigates a regulatory pathway involving calcium influx into cardiac mitochondria, which may be targeted for treating heart failure. It focuses on mitochondrial calcium uniporter stability, its regulation by Complex I dysfunction, and potential therapeutic manipulation in mouse models. The study proposes to explore a novel regulatory pathway involving calcium influx into mitochondria, which may offer new therapeutic targets for mitochondrial cardiomyopathies.