Award
National Heart, Lung, and Blood Institute 5R01HL180711-02
Role of hexokinase 3 in macrophage polarization and cardiac remodeling after myocardial infraction
Recipient
University of Arizona, Tucson, AZ
Award Amount
$667,337.00
Ceiling
$667,337.00
Awarded
June 26, 2026
Identifier
5R01HL180711-02
Research project funded to study the role of hexokinase 3 in macrophage polarization and cardiac remodeling after myocardial infarction, focusing on protective mechanisms and cardiac function.
Description
This project aims to assess HK3's role in macrophage polarization and its protective effects against cardiac damage post-myocardial infarction. The study will explore mechanisms involving NRF2 activation, glutathione production, and ROS levels, and will evaluate the impact of HK3 deletion on cardiac remodeling and function.