Award
NIH Reporter #4R00AA031313-03
RNA splicing regulation during alcohol withdrawal
Recipient
Loyola University Chicago, Maywood, IL
Award Amount
$248,997.00
Ceiling
$248,997.00
Awarded
September 16, 2025
Identifier
4R00AA031313-03
The award supports research on how chronic alcohol exposure affects RNA splicing and gene expression, particularly through the splicing factor PCBP1, to understand molecular changes and negative affective states during alcohol withdrawal.
Description
This project investigates RNA splicing, focusing on PCBP1, as a mechanism by which alcohol exposure and withdrawal lead to molecular alterations and negative affective states. The study involves manipulating PCBP1 expression, identifying PCBP1 targets, and analyzing alternatively spliced transcripts during alcohol exposure and withdrawal to provide insights into molecular mechanisms underlying alcohol withdrawal-induced changes and negative states.