# NIH Reporter #1U01CA307238-01A1

Metabolism of dietary fatty acids promotes castration resistance in prostate cancer

**Recipient:** University of Georgia, Athens, GA

**Award Amount:** $587,112.00
**Ceiling:** $587,112.00

**Awarded:** September 10, 2026

**Identifier:** 1U01CA307238-01A1

This NIH-funded project studies the role of dietary fatty acid metabolism in promoting castration resistance in prostate cancer, using various experimental models to uncover molecular mechanisms and potential therapeutic targets.

### Description

The project investigates how high-fatty-acid diets promote prostate cancer resistance to castration. The study involves designing fatty acid-enriched diets, in vitro and in vivo models, including transgenic mice and patient-derived xenograft models. The goal is to understand fatty acid metabolism's role in prostate cancer progression and resistance to therapy.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11444313)