# NIH Reporter #1R61NS146000-01A1

Generation of a CCL2-CGRP Bispecific Neutralizing Antibody to Treat Chronic Post-Traumatic Headache

**Recipient:** Washington University

**Award Amount:** $816,375.00
**Ceiling:** $816,375.00

**Awarded:** September 17, 2026

**Identifier:** 1R61NS146000-01A1

NIH-funded research to develop and evaluate a CCL2-CGRP bispecific antibody for chronic post-traumatic headache.

### Description

Develop a bispecific neutralizing antibody that simultaneously targets CCL2 and CGRP as a potential non-opioid treatment for chronic post-traumatic headache. The project includes antibody generation, humanization and engineering, and preclinical testing.

[View original record](https://reporter.nih.gov/search/0ftClcwKYUOEq8QKPKx2lA/project-details/11418123)