Award
National Cancer Institute 3R01CA266641-04S1
Investigating the role of KAT6A in MLL-rearranged acute myeloid leukemia
Recipient
University of Pennsylvania
Award Amount
$72,750.00
Ceiling
$72,750.00
Awarded
September 16, 2025
Identifier
3R01CA266641-04S1
Research project funded by the National Cancer Institute to study the role of KAT6A in acute myeloid leukemia and explore therapeutic strategies targeting KAT6A.
Description
This project aims to determine the mechanisms by which KAT6A and the ENL protein cooperate to activate promoters of AML oncogenes, and to evaluate the therapeutic potential of targeting KAT6A alone or in combination with LSD1 or DOT1L inhibitors in genetically-defined AML mouse models and clinical samples.