Award
National Human Genome Research Institute 5R01HG013472-03
Genome-wide assessment of transcriptional state history
Recipient
University of Colorado Denver
Award Amount
$390,000.00
Ceiling
$390,000.00
Awarded
May 05, 2026
Identifier
5R01HG013472-03
This NIH-funded project develops a technology to record genome-wide transcriptional activity, enabling studies of cellular history and responses in development and disease.
Description
This project aims to develop a novel technology called transcriptional endpoint marking (TEM) to create a genome-wide record of transcriptional activity in cells. The method involves introducing a permanent genetic mark at actively transcribed genes, enabling the reconstruction of cellular history and responses to various stimuli, including chemotherapy resistance and developmental processes.