Award
National Institute of General Medical Sciences 5R35GM150992-04
Mechanistic insights into translesion synthesis-dependent genome instability
Recipient
University of Vermont & St. College
Award Amount
$378,240.00
Ceiling
$378,240.00
Awarded
July 29, 2026
Identifier
5R35GM150992-04
The award supports research to understand how the REV1 polymerase controls genome instability and cellular metabolism, potentially redefining its role in disease progression and offering new therapeutic avenues.
Description
This project aims to elucidate the molecular mechanisms by which REV1 influences genome stability and cellular processes. The research could lead to novel therapeutic strategies for diseases related to genome instability. The study focuses on the role of the REV1 polymerase in genome instability, autophagy, mitosis fidelity, and cellular metabolism, with implications for cancer, neurodegenerative disorders, and other diseases.