Award
NIH Reporter #5R01HL036024-36
Mechanistic role of membrane pore formation in lung-endothelial barrier failure due to blood-borne pathogens.
Recipient
COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY, UNITED STATES
Award Amount
$750,943.00
Ceiling
$750,943.00
Awarded
August 05, 2025
Identifier
5R01HL036024-36
Research to understand and target endothelial pore formation in sepsis-induced ARDS caused by Pseudomonas aeruginosa bacteremia, aiming to develop potential therapies.
Description
This project aims to achieve understanding of mechanisms underlying sepsis-induced ARDS due to Pseudomonas aeruginosa (PA) bacteremia. The novel premise is that PA causes endothelial pore formation, leading to endothelial barrier failure. The goals are to understand these processes and evaluate pore-inhibiting strategies as potential cures for ARDS.