Award
National Eye Institute 1F30EY038545-01
Therapeutic targeting of TMEM97 to restore cholesterol homeostasis in demyelinating eye disease
Recipient
National Eye Institute (NEI), part of the NIH
Award Amount
$55,114.00
Ceiling
$55,114.00
Awarded
June 16, 2026
Identifier
1F30EY038545-01
The project focuses on understanding TMEM97's role in cholesterol trafficking and its potential as a therapeutic target for demyelinating eye diseases, involving in vitro and in vivo studies funded by NIH NEI.
Description
This project aims to elucidate the role of TMEM97 in cholesterol homeostasis within oligodendrocytes and assess its potential as a therapeutic target to promote remyelination in optic neuritis, a demyelinating eye disease. The research includes molecular, cellular, and animal model studies, with a focus on translational implications for vision preservation.