Award
National Institute of General Medical Sciences 5R01GM120430-08
Mapping deep evolutionary divergences in cellular models of stress response
Recipient
University of California Berkeley, Berkeley, CA, United States
Award Amount
$460,168.00
Ceiling
$460,168.00
Awarded
February 25, 2025
Identifier
5R01GM120430-08
This award supports research to develop and apply genetic mapping methods to study evolutionary divergences in stress response traits using yeast and mouse models, aiming to understand polygenic adaptations across species.
Description
Understanding how nature builds new traits is a fundamental goal of evolutionary genetics. This project develops and applies RH-seq, an approach for unbiased mapping of natural trait variation applicable to reproductively isolated species, to study complex genetics of ancient traits in yeast and mouse models. The research aims to advance methods for analyzing polygenic traits differing between species and accelerate dissection of ancient characters across Eukarya.