Award
National Cancer Institute 1R01CA305375-01
Pre-synaptic events in homologous recombination and maintenance of genomic stability
Recipient
Saint Louis University
Award Amount
$524,815.00
Ceiling
$524,815.00
Awarded
August 27, 2025
Identifier
1R01CA305375-01
Research project funded by the National Cancer Institute to study molecular mechanisms of DNA repair via homologous recombination, focusing on Rad51 filament formation and regulation to maintain genomic stability and prevent cancer.
Description
This project focuses on deciphering the mechanisms of homologous recombination (HR) in DNA repair, specifically how pre-synaptic events are coordinated to maintain genomic stability. It involves studying Rad51 filament formation, mediator proteins like Rad52 and BRCA2, and Rad51 paralogs, using advanced microscopy, structural mass spectrometry, and C-trap analysis.