Award
National Heart, Lung, and Blood Institute 7R01HL160808-04
HUMAN PLATELET PAR4: NOVEL ACTIVATION, INTERINDIVIDUAL VARIATION, AND NEUTROPHIL INTERACTIONS IN VIVO AND IN VITRO
Recipient
Washington University
Award Amount
$509,165.00
Ceiling
$509,165.00
Awarded
January 07, 2025
Identifier
7R01HL160808-04
NIH grant awarded to Washington University to study platelet receptor PAR4 and its genetic variants in relation to stroke and vascular disease, aiming to develop personalized anti-platelet therapies.
Description
This project aims to understand the molecular genetic mechanisms contributing to blood platelet reactivity and stroke outcomes, focusing on PAR4 receptor interactions and genetic variants such as Ala120Thr. The research involves in vivo and in vitro models, including genetically altered mouse lines, to study platelet and neutrophil activities in stroke and brain hemorrhage, ultimately supporting individualized anti-platelet therapies.