Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1R21HD117159-01A1
Asymmetric RNA segregation in neural stem cells
Recipient
University of Washington, Seattle, WA
Award Amount
$392,004.00
Ceiling
$392,004.00
Awarded
July 30, 2025
Identifier
1R21HD117159-01A1
Research project funded by NICHD to study asymmetric RNA segregation in neural stem cells using advanced molecular and imaging techniques, aiming to understand cell polarization and division relevant to neurodevelopmental disorders and cancer.
Description
This project focuses on asymmetric cell division as a mechanism to create cellular diversity, specifically investigating asymmetrically segregating RNAs in neural stem cells of Drosophila neuroblasts. The research aims to identify and characterize polarized RNAs using innovative in situ biotinylation, live cell imaging, and RNA sequencing techniques. The goal is to understand principles of cell polarization and asymmetric division that may be conserved across species, with implications for neurodevelopmental disorders and cancer.