Award
National Institute of Allergy and Infectious Diseases 5R01AI172905-04
Hypoxia, tuberculosis, and T cell dysfunction
Recipient
University of Massachusetts Medical School Worcester
Award Amount
$680,174.00
Ceiling
$680,174.00
Awarded
May 28, 2026
Identifier
5R01AI172905-04
Research project funded by NIAID to study the impact of metabolic stress and hypoxia on T cell dysfunction in tuberculosis, aiming to improve immune response and TB control through metabolic interventions.
Description
This project focuses on understanding how metabolic stress and hypoxia contribute to T cell dysfunction in tuberculosis, with the goal of developing metabolic therapeutics to improve TB outcomes. The study investigates how hypoxia affects T cell function in vivo using hypoxia fate reporter mice, and how metabolic interventions can alter T cell function and TB outcomes.