Award
National Institute of Neurological Disorders and Stroke 5R01NS119165-03
Translational Approaches to Mitigate Enhanced Alzheimer’s Disease Risk Following a Mild TBI
Recipient
University of Kentucky
Award Amount
$344,250.00
Ceiling
$344,250.00
Awarded
March 12, 2025
Identifier
5R01NS119165-03
This NIH-funded project investigates Beta hydroxybutyrate as a treatment to mitigate Alzheimer's disease risk following mild traumatic brain injury by targeting mitochondrial function and neuroinflammation.
Description
A multi-year NIH research project focused on exploring the therapeutic potential of Beta hydroxybutyrate (BHB) to reduce the risk of neurodegenerative disease post-traumatic brain injury (TBI). The study tests BHB's effects on mitochondrial function and neuroinflammation in mouse models and defines its immunomodulatory properties via the HCA2 receptor.