Award
NIH Reporter #5R35GM125005-10
Chemoenzymatic Synthesis, Mode of Action and Evolution of Natural Product-based Macrocycles
Recipient
University of North Carolina Chapel Hill
Award Amount
$389,341.00
Ceiling
$389,341.00
Awarded
August 12, 2026
Identifier
5R35GM125005-10
Research grant for chemoenzymatic synthesis and evolution of natural product-based macrocycles to develop new therapeutic scaffolds and study cancer inhibition mechanisms.
Description
A research grant awarded by the National Institute of General Medical Sciences (NIGMS) for a project on chemoenzymatic synthesis and evolution of natural product-based macrocycles. The project aims to develop new therapeutic scaffolds and understand mechanisms of inhibiting cancer by targeting protein interfaces. The project involves natural product biosynthesis, enzyme promiscuity, peptide macrocycles, and therapeutic target engagement.