National Library of Medicine 5R01LM013879-04

Penalized mixture cure models for identifying genomic features associated with outcome in acute myeloid leukemia

This award funds research to develop advanced statistical models for analyzing high-dimensional genomic data in acute myeloid leukemia (AML), focusing on improving survival analysis for cured patients and identifying molecular features associated with outcomes. The project includes software development and application to clinical datasets.

Description

Development of penalized mixture cure models for high-dimensional genomic data in AML to improve survival analysis techniques for cured patients using high-dimensional genomic data. The project includes developing penalized parametric and semi-parametric mixture cure models, performing simulation studies, developing software, and applying methods to AML datasets to enhance risk stratification systems.

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