Award
National Institute of Allergy and Infectious Diseases 1R01AI195649-01
Intrinsic STING signaling shapes phagocytosis-dependent innate immunity
Recipient
Ohio State University, Columbus, OH
Award Amount
$787,498.00
Ceiling
$787,498.00
Awarded
February 19, 2026
Identifier
1R01AI195649-01
NIH grant awarded to Ohio State University to study the role of STING signaling in innate immunity and its implications for cancer therapy and microbial infections.
Description
This NIH grant opportunity focuses on the role of intrinsic STING signaling in shaping phagocytosis-dependent innate immunity. The project aims to elucidate how STING facilitates activation of phagocytes and cross-presentation of microbial or tumor antigens, with objectives including evaluating mechanisms by which STING signaling renders infected or damaged cells immunogenic, reconstituting STING signaling in aged or transformed cells, investigating epigenetic silencing of STING, and developing strategies to overcome resistance to cancer therapies.