Award
National Institute of Allergy and Infectious Diseases 5R01AI146257-06
Gut microbiome communication with the bone marrow regulates intestinal inflammation.
Recipient
Methodist Hospital Research Institute
Award Amount
$403,750.00
Ceiling
$403,750.00
Awarded
March 28, 2025
Identifier
5R01AI146257-06
Research project funded by NIAID studying gut microbiome's role in regulating intestinal inflammation through bone marrow communication, focusing on innate immunity and epigenetic changes.
Description
This project investigates how the gut microbiota communicates with the bone marrow to alter gut inflammation and protect from infection with enteric pathogens. The project aims to understand mechanisms of microbiota-induced trained innate immunity and epigenetic changes in the bone marrow.