Award
NIH Reporter #2R35GM142537-06
Mechanisms underpinning meiotic spindle formation and behavior
Recipient
University of Missouri-Columbia
Award Amount
$407,219.00
Ceiling
$407,219.00
Awarded
July 29, 2026
Identifier
2R35GM142537-06
Research project funded by NIGMS to study molecular mechanisms of female meiosis, focusing on spindle formation and positioning to reduce chromosome segregation errors causing developmental disorders.
Description
This project aims to understand the molecular mechanisms regulating female meiosis, focusing on spindle formation and positioning in oocytes lacking centrioles. The research will employ transgenic mouse models, genetic manipulation, optogenetics, and live imaging to investigate the regulation of microtubule organizing centers (MTOCs), the interaction between F-actin and microtubules, and the regulation of spindle-localized F-actin. The goal is to elucidate how these processes ensure accurate chromosome segregation and reduce errors during meiosis.