Award
NIH Reporter #11288096
Longitudinal Multiparametric Magnetic Resonance Imaging of Outbred Rats with Variable Vulnerability to the Development of Oxycodone Addiction-like Behaviors
Recipient
University of California, San Diego
Award Amount
$239,125.00
Ceiling
$239,125.00
Awarded
February 20, 2026
Identifier
11288096
The project uses longitudinal multi-parametric MRI on genetically heterogeneous rats to identify brain features linked to vulnerability or resilience to oxycodone addiction, aiming to inform personalized prevention and treatment of opioid use disorder.
Description
This research aims to unravel brain differences related to individual vulnerability to oxycodone use disorder through longitudinal imaging of a rat model mimicking human variability. The study integrates preclinical and clinical approaches to develop personalized strategies for preventing and treating opioid use disorder.