Award
NIH Reporter #5R01AI172027-05
Microbiota-derived metabolites and the regulation of host immunity and inflammation
Recipient
WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY, UNITED STATES
Award Amount
$805,745.00
Ceiling
$805,745.00
Awarded
June 03, 2026
Identifier
5R01AI172027-05
Research funded by NIH/NIAID to study how microbiota-derived metabolites influence host immunity and inflammation, particularly in response to helminth infections, with potential for new therapeutic strategies.
Description
This project investigates the role of microbiota-derived metabolites in regulating immune responses to helminth infections, focusing on how dietary fiber impacts microbiota composition and immune modulation. It aims to identify microbiota-derived metabolites that activate ILC2s and regulate bile acid pathways affecting immunity, addressing the global health burden of soil-transmitted helminth infections.