Award
NIH Reporter #5R35GM118129-10
Mechanisms of DNA replication and maintenance in eukaryotes
Recipient
Washington University in Saint Louis
Award Amount
$697,356.00
Ceiling
$697,356.00
Awarded
June 01, 2016
Identifier
5R35GM118129-10
This NIH/NIGMS award funds research on DNA replication and maintenance in eukaryotic cells, led by Professor Peter M Burgers at Washington University in Saint Louis, with a focus on biochemical and structural studies to understand DNA replication mechanisms and response pathways.
Description
The project focuses on DNA replication mechanisms and DNA maintenance in eukaryotic cells, using biochemical, biophysical, genetic, and structural studies. The research involves DNA damage response pathways, DNA polymerases, cell cycle checkpoints, lagging strand DNA replication, Okazaki fragment maturation, Cryo-EM studies, and mutagenesis. The project aims to understand the coupling between replication arrest and downstream response pathways.