Award
National Institute of Mental Health 11184375
5/5 Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)
Recipient
National Institute of Mental Health (NIMH)
Award Amount
$397,916.00
Ceiling
$397,916.00
Awarded
August 18, 2025
Identifier
11184375
This award funds a project to develop a biomarker-based decision support tool for early schizophrenia treatment through a multi-center clinical trial, aiming to improve patient outcomes and precision psychiatry.
Description
The project aims to develop a clozapine decision support tool based on biomarkers for first episode psychosis. The study involves a multi-center, randomized clinical trial with 410 participants. The biomarkers include resting state fMRI and genetic tests. The goal is to improve patient outcomes and develop a precision psychiatry tool. The project involves collaboration with people with lived experience of psychosis and family members. The study will evaluate clinical response, brain patterns, and develop a decision support tool for early intervention.