Award
NIH Reporter #5R37CA262635-05
Dissecting the Role Ubiquitin E3 Ligase UBR5 in Lymphomagenesis
Recipient
Utah State Higher Education System--University of Utah, Salt Lake City, UT
Award Amount
$386,561.00
Ceiling
$386,561.00
Awarded
July 23, 2025
Identifier
5R37CA262635-05
Research project funded by the National Cancer Institute to study the role of UBR5 mutations in mantle cell lymphoma, aiming to understand disease progression and identify therapeutic targets.
Description
This project focuses on the ubiquitin E3 ligase UBR5, which is frequently mutated in mantle cell lymphoma (MCL), a rare and aggressive non-Hodgkin’s lymphoma. The study aims to elucidate the role of UBR5 mutations in lymphomagenesis, explore molecular pathways involved, and identify potential therapeutic targets using advanced genetic models, proteomic analyses, and molecular biology techniques.