Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R00HD106861-05
Identifying inter-kingdom microbial determinants of altered immunity in HIV exposed infants
Recipient
University of California Riverside
Award Amount
$239,912.00
Ceiling
$239,912.00
Awarded
July 03, 2026
Identifier
5R00HD106861-05
Research project funded by NICHD to study how the enteric virome affects immunity and vaccine responses in HIV-exposed infants, aiming to identify mechanisms of gut dysbiosis and potential therapeutics.
Description
This project aims to elucidate the role of the enteric virome in shaping immune responses in HIV-exposed infants, with potential implications for therapeutic interventions. The study will investigate interactions between viruses, bacterial microbiota, and cellular responses to vaccination in HIV-exposed uninfected infants compared to unexposed infants, using cohort data and gnotobiotic mouse models, along with single-cell RNA sequencing.