Award
National Institute of Neurological Disorders and Stroke 5R01NS140152-02
Endothelin signaling in neural stem cell homeostasis and remyelination
Recipient
University of Notre Dame, IN, United States
Award Amount
$424,106.00
Ceiling
$424,106.00
Awarded
July 14, 2026
Identifier
5R01NS140152-02
Research project funded by NINDS to study Endothelin-1 signaling in neural stem cells for remyelination, aiming to develop therapies for neurodegenerative diseases like Multiple Sclerosis.
Description
This project investigates how Endothelin-1 signaling, derived from endothelial cells and part of the neurovascular unit, maintains neural stem cell quiescence and promotes remyelination. Using conditional knockout mice and the cuprizone demyelination model, the study aims to elucidate the pathway's role in neural stem cell behavior and remyelination, potentially leading to new therapeutic strategies.