Award
NIH Reporter #5R01HL176323-03
Novel mechanisms of HIV-associated pulmonary vascular disease
Recipient
Augusta University, Augusta, GA, United States
Award Amount
$760,760.00
Ceiling
$760,760.00
Awarded
June 10, 2026
Identifier
5R01HL176323-03
This award funds research to understand how HIV proteins contribute to pulmonary vascular disease in people with HIV, aiming to identify new therapeutic targets.
Description
The study aims to investigate whether HIV-derived proteins, which remain in circulation despite combination antiretroviral therapy and well-controlled viremia, contribute to the development of pulmonary vascular disease (PVD) in people with HIV. The research explores mechanisms involving Podnl1-dependent pathways, IL-1α-mediated effects, and the role of HIV-Tat protein in pulmonary artery remodeling, with the goal of identifying new therapeutic targets.