Award
National Institute of General Medical Sciences 2R15GM134495-02A1
Functional Analysis of Locus-Specific Pericentric Satellite Expression
Recipient
Swarthmore College
Award Amount
$437,442.00
Ceiling
$437,442.00
Awarded
August 05, 2024
Identifier
2R15GM134495-02A1
This NIH-funded project studies the function and expression of satellite DNA sequences near centromeres, particularly their aberrant expression in cancer cells, using genomic and RNA structural analyses. It also provides undergraduate research training.
Description
The project aims to understand the basic function of specific DNA sequences near chromosomal centromeres, focusing on tandemly repeated satellite DNA sequences and their misregulation in cancer cells. It involves mapping chromosome-specific HSATII variants, analyzing sequence motifs, and studying phenotypic effects including RNA structure and protein interactions. Undergraduate students will conduct the research, gaining experience in genomics and RNA structural analysis.