Award
National Institute of Neurological Disorders and Stroke 5R01NS118669-04
Blinded Comparison of Different Alpha-Synuclein Seeding Assays as Cutaneous Biomarkers of Lewy Body Dementias
Recipient
National Institute of Neurological Disorders and Stroke (NINDS), part of NIH
Award Amount
$571,411.00
Ceiling
$571,411.00
Awarded
August 12, 2024
Identifier
5R01NS118669-04
This NIH/NINDS funded project evaluates alpha-synuclein seeding assays as diagnostic biomarkers for Lewy Body Dementias through blinded comparisons and longitudinal clinical assessments.
Description
The project involves assessing alpha-synuclein in punch biopsies of the skin using new seeding assay diagnostic methods. It aims to confirm the diagnostic utility of seeding assays for Lewy Body Dementias by performing blinded assays across multiple laboratories and comparing results with immunohistochemistry, including longitudinal assessments of cognitive and motor decline. The project is part of the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND).