Award
NIH Reporter #5R01CA276112-04
Consequences of retrotransposition on genome integrity
Recipient
Dana-Farber Cancer Institute
Award Amount
$735,573.00
Ceiling
$735,573.00
Awarded
August 06, 2026
Identifier
5R01CA276112-04
Research project funded by the National Cancer Institute to study how DNA transposons contribute to genome instability and cancer progression, particularly in Barrett's esophagus leading to esophageal cancer.
Description
This project investigates the roles of DNA-damaging transposons during tumorigenesis, focusing on their contributions to the progression of Barrett's esophagus to esophageal cancer. Using in vitro systems and genomic analysis in human tissues, the study aims to determine the full scope of DNA rearrangements attributable to transposon activity. The research hypothesizes that retrotransposition promotes cancer evolution by causing long-range genomic rearrangements, destabilizing genomes, and promoting tumorigenesis.