Award
NIH Reporter #5R01HG012445-05
Mendelian inheritance of artificial chromosomes
Recipient
University of Pennsylvania, Department of Biochemistry
Award Amount
$1,169,628.00
Ceiling
$1,169,628.00
Awarded
July 31, 2025
Identifier
5R01HG012445-05
Award for research on synthetic mammalian artificial chromosomes to improve genome engineering and synthetic biology, funded by NHGRI at University of Pennsylvania.
Description
The project involves constructing synthetic mammalian artificial chromosomes (MACs) with faithful inheritance through the germline, using mouse as a model system. The project aims to advance genome engineering capabilities and synthetic biology applications. The project emphasizes innovation in designing MAC vectors, assembling large synthetic DNA, and creating animals for in vivo testing.