Award
NIH Reporter #5R01HL163604-04
Genetic and Immuno-inflammatory Drivers of Post-acute Pulmonary Sequelae of SARS-CoV-2
Recipient
New York University School of Medicine
Award Amount
$825,025.00
Ceiling
$825,025.00
Awarded
May 12, 2026
Identifier
5R01HL163604-04
This award funds research to investigate genetic and immuno-inflammatory factors driving long-term pulmonary complications after COVID-19, aiming to identify mechanisms and therapeutic targets.
Description
The goal of this proposal is to study the frequency, chronicity, and etiology of post-acute sequelae of SARS-CoV-2 (PASC) with protocols designed to characterize genetic and immuno-inflammatory factors that influence post-COVID complications. The study will establish a cohort of over 1200 deeply phenotyped SARS-CoV-2 patients to determine long-term effects, focusing on pulmonary function, autoantibody profiles, cytokine levels, and genetic risk scores. The research aims to better understand pathogenetic mechanisms and identify therapeutic targets for post-acute sequelae.