Award
National Institute of Diabetes and Digestive and Kidney Diseases 11369561
PNPase inhibition as an effective treatment for chronic bladder pain
Recipient
University of Pittsburgh at Pittsburgh
Award Amount
$1,571,034.00
Ceiling
$1,571,034.00
Awarded
August 07, 2025
Identifier
11369561
This NIH grant supports research on PNPase inhibition as a novel treatment for chronic bladder pain, aiming to provide non-opioid therapeutic options and advance clinical practice.
Description
The project focuses on validating a non-opioid target, purine nucleoside phosphorylase (PNPase), for treating visceral pain disorders such as IC/BPS. The project involves multidisciplinary approaches, including pharmacologic inhibition and molecular knockdown of PNPase. The research aims to shift current paradigms in clinical practice and research.