Award
National Institute of Allergy and Infectious Diseases 5R01AI185510-02
Influence of hypoxia on the antiviral functions of human intestinal epithelial cells
Recipient
University of Florida, Gainesville, FL
Award Amount
$646,188.00
Ceiling
$646,188.00
Awarded
April 03, 2026
Identifier
5R01AI185510-02
Research project funded by NIAID to study the impact of hypoxia on antiviral functions in human intestinal epithelial cells, aiming to develop therapeutics for enteric viruses and related diseases.
Description
This project investigates how hypoxia impairs innate immune responses in human intestinal epithelial cells, favoring viral replication. It employs human enteric viruses, intestinal organoids, and gut-on-a-chip technologies to understand cell-specific responses to hypoxia, develop novel therapeutics targeting hypoxia responses, and explore implications for other enteric pathogens and inflammatory bowel diseases.