Award
NIH Reporter #5R01EB035631-02
Enabling systemic delivery of europium-containing contrast agents for magnetic resonance imaging
Recipient
Wayne State University, Detroit, MI, United States
Award Amount
$555,123.00
Ceiling
$555,123.00
Awarded
March 25, 2026
Identifier
5R01EB035631-02
This NIH grant supports research to develop europium-based MRI contrast agents for systemic delivery to image hypoxia, which is relevant to many diseases including kidney disease and cancers.
Description
The research aims to develop hypoxia-sensing probes for MRI to target unmet needs in diagnostic medicine relevant to a range of diseases. The project focuses on phosphonate-containing complexes of EuII that are compatible with systemic delivery, addressing challenges such as persistence time and relaxivity. The goal is to enable systemic delivery of EuII for imaging hypoxia in multiple diseases, building on previous discoveries of EuII-based molecules.