Award
NIH Reporter #5R01HL169202-03
Molecular mechanisms of progranulin as a regulator of endothelial biology and blood pressure control
Recipient
University of South Alabama, Mobile, AL
Award Amount
$463,961.00
Ceiling
$463,961.00
Awarded
June 03, 2026
Identifier
5R01HL169202-03
Research project funded by the National Heart Lung and Blood Institute to study the role of progranulin in endothelial function and blood pressure regulation, aiming to identify new therapeutic targets for hypertension-related cardiovascular diseases.
Description
This study investigates the role of endothelial progranulin (PGRN) and its autocrine actions in regulating endothelial function and blood pressure. Using genetically modified mice, gain and loss-of-function experiments, and advanced vascular methods, the research aims to establish PGRN as a novel therapeutic target for hypertension-related cardiovascular diseases.