Award
National Institute of General Medical Sciences 5R01GM145647-05
Deciphering the Enzymatic Mechanism of Superoxide Dismutase
Recipient
University of Nebraska Medical Center, Omaha, NE, United States
Award Amount
$431,383.00
Ceiling
$431,383.00
Awarded
April 28, 2026
Identifier
5R01GM145647-05
This award funds a research project at the University of Nebraska Medical Center to study the enzymatic mechanism of MnSOD, focusing on proton transfer mechanisms using advanced neutron crystallography and computational methods to better understand oxidative stress regulation.
Description
Research project to understand the molecular basis of how mitochondrial manganese superoxide dismutase (MnSOD) uses coupled proton-electron transfers to dismute superoxide, using neutron crystallography, spectroscopy, and computational chemistry to reveal proton relays and protonation states at the active site metal.