Award
National Cancer Institute 3R01CA259037-05S1
Tuning PARP-1 retention and release on DNA breaks
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$123,563.00
Ceiling
$123,563.00
Awarded
March 05, 2026
Identifier
3R01CA259037-05S1
This award supports a research project investigating the mechanisms of PARP-1 activity in DNA repair and its inhibition for cancer therapy, using advanced structural and biochemical methods.
Description
Research project focused on understanding the activation, modulation, and inhibition of PARP-1 in DNA damage response, with applications in cancer therapy. The study employs structural, biochemical, and medicinal chemistry approaches to develop new small molecule tools and potential medicines.