NIH Reporter #5R35CA263922-04

Interaction between nuclear epigenetic and metabolic pathways in cancer

A multidisciplinary NIH-funded research project investigating the interaction between nuclear epigenetic and metabolic pathways in cancer, aiming to understand mechanisms and develop targeted inhibitors with therapeutic potential.

Description

This project focuses on the dysregulation of epigenetic and metabolic pathways in cancer, exploring their roles in gene expression regulation and tumor formation. The research aims to investigate novel epigenetic regulation mechanisms and their intersection with nuclear metabolism, using cell lines and mouse models. Key areas include the study of DNA regulatory elements called enhancers, the role of nuclear speckles in p53 gene target trafficking, and the nuclear metabolic-epigenetic axis. The project has developed an inhibitor targeting the nuclear metabolic enzyme ACSS2, with potential therapeutic implications.

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