Award
National Heart, Lung, and Blood Institute 1F32HL182304-01
Defining the function of C/EBP-beta and its downstream target PSMB9 in atherosclerosis
Recipient
Emory University
Award Amount
$81,040.00
Ceiling
$81,040.00
Awarded
September 12, 2025
Identifier
1F32HL182304-01
The project funded by the National Heart Lung and Blood Institute studies the roles of C/EBP-beta and PSMB9 proteins in atherosclerosis development, aiming to understand their involvement in inflammation and endothelial dysfunction caused by disturbed blood flow, potentially leading to new therapeutic targets.
Description
This NIH project aims to elucidate the roles of specific proteins in the development of atherosclerosis related to disturbed blood flow, with potential implications for new treatments. The project investigates the molecular mechanisms by which disturbed blood flow induces endothelial inflammation and contributes to atherosclerosis, focusing on the roles of C/EBPβ and PSMB9. The findings could identify novel targets for therapeutic intervention to prevent or treat cardiovascular disease.