Award
National Institute on Aging 7K01AG090892-02
Stress and aging: longitudinal evaluation of synaptic changes using in vivo SV2A PET
Recipient
UT Southwestern Medical Center
Award Amount
$127,386.00
Ceiling
$127,386.00
Awarded
March 05, 2026
Identifier
7K01AG090892-02
NIH funded research project to study the effects of chronic stress and aging on synaptic density using in vivo SV2A PET imaging in animal models, aiming to understand brain aging and cognitive decline.
Description
This project aims to evaluate the effect of chronic stress on synaptic density using in vivo SV2A PET imaging in an animal model, investigate the impact of age on stress-induced synaptic changes, and explore relationships between stress- and age-related synaptic changes with cognitive function. The study will provide insights into synaptic mechanisms contributing to stress-accelerated brain aging and cognitive decline.