Award
National Institute of Allergy and Infectious Diseases 1R21AI200041-01
Understanding the impact of human protein coding variation on STING function.
Recipient
CASE WESTERN RESERVE UNIVERSITY
Award Amount
$235,500.00
Ceiling
$235,500.00
Awarded
June 16, 2026
Identifier
1R21AI200041-01
A research project funded to study the effects of human protein coding variations on STING function, focusing on mutations linked to severe inflammatory diseases, with the goal of identifying new disease mechanisms and therapeutic targets.
Description
This project aims to develop high-throughput, multiplexable assays to systematically characterize how SAVI mutations affect STING-mediated transcription, autophagy, and cell death across common human genetic backgrounds. The work will illuminate novel disease mechanisms and potential therapeutic targets, advancing understanding of STING-related inflammatory disorders.