# NIH Reporter #5R01MH134893-04

Mitochondrial influences on blood brain barrier function and neuropsychiatric illness

**Recipient:** University of Pennsylvania

**Award Amount:** $674,894.00
**Ceiling:** $674,894.00

**Awarded:** October 28, 2026

**Identifier:** 5R01MH134893-04

NIH-funded research on mitochondrial dysfunction and blood-brain barrier impairment related to neuropsychiatric illness, including potential therapeutic approaches.

### Description

The project examines how mitochondrial energetic compromise interacts with structural weaknesses in the blood-brain barrier in 22q11.2 deletion syndrome, and whether interventions that improve mitochondrial energetics can improve barrier function.

[View original record](https://reporter.nih.gov/search/a_XEnEpPR0i-06zXlbqcPw/project-details/11458942)