Award
National Cancer Institute 5U01CA264620-05
Mechanism of estrogen independent proliferation in ER+ breast cancer cells
Recipient
BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
Award Amount
$577,234.00
Ceiling
$577,234.00
Awarded
August 25, 2025
Identifier
5U01CA264620-05
This award funds a research project to understand and overcome resistance mechanisms in ER+ breast cancer by studying cell cycle regulation and signaling pathways, aiming to improve treatment durability.
Description
Research project investigating mechanisms of resistance to CDK4/6 inhibition in early stage estrogen receptor positive breast cancer, focusing on JNK MAPK pathway stimulation and cell cycle reactivation, using mechanistic models, patient tumor analysis, and drug testing to guide therapeutic strategies.