Award
National Institute on Aging 1R21AG083593-01
Investigate the utility of APLP1 as an endosomal biomarker for Alzheimer's Disease in Down Syndrome
Recipient
Columbia University Health Sciences
Award Amount
$452,375.00
Ceiling
$452,375.00
Awarded
August 15, 2023
Identifier
1R21AG083593-01
A research project funded by the National Institute on Aging to validate n-APLP1 as an early biomarker for Alzheimer's Disease in individuals with Down Syndrome, aiming to support early detection and therapeutic trials.
Description
This project aims to develop and validate new biomarkers of endosomal dysfunction, focusing on proteins such as n-APLP1, which may serve as early indicators of Alzheimer's Disease progression in individuals with Down Syndrome. The research focuses on validation of biomarkers related to endosomal trafficking defects, with potential to accelerate drug discovery and early detection of Alzheimer's Disease in Down Syndrome populations.